An oral redox-sensitive self-immolating prodrug strategy.
نویسندگان
چکیده
We report a novel oral prodrug approach where a solubilizing polymer conjugated to the drug is designed to be released by the action of an exogenously administered agent in the intestine. A redox-sensitive self-immolating design was implemented, and the reconversion kinetics were studied for three reducible prodrugs.
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عنوان ژورنال:
- Chemical communications
دوره 51 26 شماره
صفحات -
تاریخ انتشار 2015